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Inactivated SALK vaccine

Gustavo Palacios ustavopa at interserver.com.ar
Tue Jan 28 05:01:58 EST 1997

D you know a way to explain why a inactivated vaccine as Salk can
generate a inmune response that protect humans to poliomyelitis since
1960 ?. I expect that an RNA virus as PV can mutate in a way to
"escape" from the inmune response generated to the same antigen ? Or
the vaccine is variated along the time as the FMDV vaccine, (that it
is other vaccine, by the way, that must to be variated to mantain
protection while the virus mutated in the field ? Do you know about
some work in this specific field ?

Thanks in advance and forgive for my English

Gustavo Palacios
Buenos Aires, Argentina

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