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HPV and computer programs

Thomas Burmeister tburmei at gwdg.de
Thu May 22 18:13:52 EST 1997

In article <5m27jg$so7 at net.bio.net>, GREGORY LAMONT CASEY
<gcasey at pacbell.net> wrote:

>I am a student of biochemistry at California State University Los
>Angeles.  My passions are bacteria and viruses.  Does anyone know of
>computer programs that have simulations of the chemical structures of
>bacteria and viruses.  I am very interested in Human Papilloma Viruses.


I do not know of any programs that could construct a 3-dimensional virus
capsid from a given amino acid sequence of the elementary capsid protein.
But as you will probably know there are several extensive electron
microscopic studies of human papillomaviruses (older work published by
Finch JT, Klug A,
Kiselec NA; you may look it up in MEDLINE; a newer study done by Baker TS
et al. 
Biophys J 60: 1445-1456 (1991) determined the capsid structure of HPV1 & BPV1
at 3 nm resolution by use of cryoelectron microscopy). Together with
immunological findings (e.g. Heino P et. al. J Gen Virol 76: 1141-1153)
one can make some assumptions which parts of the major
capsid protein are outside and which are inside the capsid shell.

Thomas Burmeister
<mailto:tburmei at gwdg.de>

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