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[Virology] Re: Adenovirus info. request (2)

adrish adrishsen at gmail.com
Fri Aug 18 09:23:34 EST 2006

Freeze-thawing a virus suspension will result in perturbation of viral
surface proteins needed for infectivity and thus a decrease in viral
titers. The same sort of thing happens when you repeatedly F/T an
enzyme preparation.

Shelly Ogiste wrote:
> Hi I was hoping you could help me with a question. How can you "lose
> titer" in a freeze thaw cycle? If I take a liquid and repeatedly freeze
> it and thaw it, how is the concentration going to change?
> Shelly

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