Hi Mark,
we have recently found two non-proline cis peptide
bonds in coagulation factor XIII. One is close to the
active site (Arg-Tyr) and the other one is at the
dimerization interface of the homodimer (Gln-Phe).
Sequence comparisons suggest that these are
conserved. See our paper in FEBS Lett. 423, 291-296 (1998).
Best wishes,
Manfred Weiss
Mark Banfield writes:
>> Hi,
>> I have a non-proline cis-peptide bond in a structure i've recently
> determined, and would like to know how many other's there are.
>> Has anyone compiled a list of protein structures containing such bonds?
> Or have any idea how i could go about compiling such a list? I've been
> unable to design a database search for these bond types, without calling
> up all the cis-prolines.
>> Thanks for any help.....
>> Mark Banfield
>> Dept. of Biochem.
> University of Bristol
> Bristol
> UK
>>
--
Manfred S. Weiss, Dr.
Institute of Molecular Biotechnology
Department of Structural Biology and Crystallography
Beutenbergstrasse 11
Postfach 100813 Phone: +49-3641-65-6070
D-07708 Jena Fax: +49-3641-65-6062
GERMANY Email: msweiss at imb-jena.de
