X-RAY CRYSTALLOGRAPHIC AND BIOCHEMICAL STUDIES OF RECOGNITION BETWEEN
LIM DOMAINS AND THEIR TARGETS
A Postdoctoral position is available jointly between the groups of
Partho Ghosh (Department of Chemistry & Biochemistry) and Gordon Gill
(Department of Medicine) at the University of California, San Diego.
We are investigating the nature and mechanism by which LIM domains
recognize their target protein sequences. The LIM domain is a widely
distributed protein structural motif responsible for protein-protein
interactions and is found in nuclear and cytoplasmic proteins.
Although the structures of several LIM domains have been previously
determined, the mechanism by which LIM domains specifically interact
with their target proteins is not known. We are undertaking a project
to investigate the interaction between LIM domains and their targets
using biochemical and X-ray crystallographic techniques.
We are looking for highly motivated and enthusiastic individuals with
backgrounds in biochemistry or structural biology. Our laboratories
are well equipped to carry out protein expression, purification,
analysis and crystallization. We share an excellent data collection
facility, which includes 3 MAR detectors and a highly brilliant Rigaku
FR5 generator, with several other laboratories.
Please send a c.v. and the names of three references to either Dr.
Partho Ghosh, Department of Chemistry & Biochemistry, 0314, UCSD, 9500
Gilman Drive, La Jolla, CA 92093 (pghosh at ucsd.edu; fax 619-534-7042) or
Dr. Gordon Gill, Department of Medicine, UCSD 9500 Gilman Drive, La
Jolla, CA 92093 (ggill at ucsd.edu).