Joint Center for Structural Genomics
The Scripps Research Institute/Genomics Institute of the Novartis Research Foundation,
Stanford University/Stanford Synchrotron Radiation Laboratory, U.C. San Diego/San
Diego Supercomputer Center along with collaborators from several other Institutes
have formed the Joint Center for Structural Genomics (JCSG). The main goal of the
Center is to advance automated high-throughput methods for all stages of macromolecular
structure determination including target selection, protein expression, purification,
crystallization, crystal manipulation, structure determination and data management.
Teams of experts are being assembled for each phase: Bioinformatics (UCSD/SDSC),
Crystallomics (TSRI/GNF) and Structure Determination (SSRL). Target selection will
focus on novel cell signaling proteins from c. elgans, human, mouse and drosophila.
The center is funded by the NIH-NIGMS Protein Structure Initiative
The JCSG is currently seeking experienced, highly skilled protein biochemists, X-ray
crystallographers, molecular biologists, engineers, scientific software developers,
scientific/technical programmers and technical support personnel.
Please visit our Web Site http://www.jcsg.org for further information and current
job opportunities or contact one of the Core Leaders or Dr Ian Wilson, The Scripps
Research Institute, wilson at scripps.edu.
Bioinformatics Positions: Research and Database Programmers, Project Scientist
and Computer Resource Specialist.
Responsibilities: Target selection, information management, structure validation
and post-structural analysis. Database Programmers will be specialists in ORDBMS.
Programmers need experience in computational science and numerical analysis. Project
Scientists need a background in molecular biology/biochemistry and proficiency in
computational methods of sequence, structure, pathway and other analytical methods.
Core Leader: Dr Shankar Subramaniam,
Dept. of Bioengineering and Dept. Chem. & Biochem.,
San Diego Supercomputing Center,
University of California San Diego,
9500 Gilman Drive,
La Jolla, CA 92037.
Email: shankar at sdsc.edu
Phone: (858) 822-0986
Crystallomics Positions: Research technicians.
Responsibilities: Protein expression, purification, crystallization, imaging and
data entry and management. Experience in either X-ray crystallography, molecular biology
or protein biochemistry required.
Core Leader: Dr Raymond Stevens
Dept. of Mol. Biol., Chemistry.
The Scripps Research Institute,
10550 N. Torrey Pines Rd
La Jolla, CA 92037.
E-mail: stevens at scripps.edu
Phone: (858) 784-9416
Structure Determination Positions: Staff Scientist, Sr. Scientific Software Developer,
Sr. Scientific Software Developer, Beam Line Engineering Physicist, Electrical Engineer and
Technical Management Administrator.
Responsibilities: Establish a high-throughput pipeline for structure determination
from initial crystal characterization to structure solution. Development of new methods and
technology for automated structure determination and robotic crystal handling.
Core Leader: Dr Peter Kuhn Dept. Biotechnology,
Stanford Synchrotron Radiation Laboratory,
2575 Sand Hill Rd, Mail Stop 69 - SLAC,
Menlo Park, CA 94025.
Email: pkuhn at ssrl.slac.stanford.edu