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[X-plor] Quite interesting Lord of the RING

Gerard DVD Kleywegt via x-plor%40net.bio.net (by gerard from xray.bmc.uu.se)
Thu May 31 11:52:38 EST 2012

Hi all,

E3 ubiquitin ligase is responsible for flagging proteins for degradation by 
transferring ubiquitin from a donor protein onto the molecule to be degraded. 
It is activated by phosphorylation of a tyrosine which promotes a huge 
conformational change, swinging its RING domain 180 degrees to put the 
enzyme's two substrates in proximity.

Read more about this enzyme and see the conformational changes happen before 
your very own eyes in this latest installment of Quips (QUite Interesting Pdb 
Structures; pdbe.org/quips) at:


If you have an interesting structure whose story you would like to tell (with 
our help) in the form of a Quips article, please contact us at pdbe from ebi.ac.uk


Gerard J. Kleywegt, PDBe, EMBL-EBI, Hinxton, UK
gerard from ebi.ac.uk ..................... pdbe.org
Secretary: Pauline Haslam  pdbe_admin from ebi.ac.uk

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