ProAnalyst


-------------------------------------------------------------------
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS IN PROTEINS, PROTEIN
ENGINEERING, PATTERNS RECOGNITION IN COMBINATORIAL LIBRARIES,
PHYSICO-CHEMICAL AND ALPHABETICAL ANALYSIS IN MULTIPLE SEQUENCE
ALIGNMENTS AND 3D STRUCTURE (VER 1.02 demo)
-------------------------------------------------------------------

State Research Center of Virology and Biotechnology "Vector" Koltsovo,
Novosibirsk Region, 633159 Russia

COPYRIGHT (C) 1996 Vladimir Ivanisenko, Alexey Eroshkin, all rights reserved.

E.mail: salex@vector.nsk.su, eroshkin@vector.nsk.su


The files required to run PROANALYST are distributed in the form of a
single compressed file. Create a directory "PANALYST" in your hard disk,
for example, C.  Copy the file to the directory, run the file from DOS
prompt and answer Yes to all questions. To start the program run 
PANALYST.EXE

PROANALYST:

o Investigation of structural differences between proteins divided by
  functional, evolutionary or other criteria;
o Structure-activity relationships investigation by multiple regression 
  and discriminant analysis;
o Searching motifs in combinatorial libraries (peptide, phage-display
  libraries, etc.) with motif mapping on the target protein;
o Protein-engineering experiments design and activity prediction;
o Intra and cross group variability analysis;
o Sorting sequences by protein activity value, protein group number and
  by motifs found;
o Alphabetical and physico-chemical analysis of protein features
  variations (in 1D and 3D structures); 
o Classic profile/plot analysis for a single sequence (hydrophobicity, 
  helical amphipathicity, etc.) suplemented with average, min, max and 
  dispresion plots for a set of sequences;
o Structure-activity determination profile (SAD);
o Mapping all obtained results on 3D structure and sequence;
o Flexible molecular graphics (stereo);
o Data conversion from several protein sequence formats (FASTA,
  SWISS-PROT, PIR, CLUSTAL);
o Has data bases with 50 aligned protein families, more than 60 amino
  acid properties, HELP, Manual and examples with program applications.

REQUIREMENTS

PROANALYST runs on the IBM  PC  family  of  computers.  
PROANALYST requires DOS 3.30 or higher and 1.4Mb of RAM; it will
run on any 80-column monitor but graphics require EGA/VGA monitor.  A
hard disk is recommended for enhancing performance of the program.