The HyperGCG stack is made available here for limited distribution, testing and comments. If you have received a mail message from me please feel free to copy and use within your work group. Everyone will benefit if you can return comments and any additions you make to the stack that may be of general use. You can return stacks here via ftp. The HyperGCG.SIT format is a MacBinary Stuffed archive. You will need to use binary ftp, and Macbinary file transfer to your mac. The HyperGCG.Hqx is a binhex encoded version of the .SIT file which can be transferred in text modes. I have put together the beginnings of a Macintosh Hypercard interface to the GCG gene sequence analysis package. It is based around the idea that each function in the GCG suite is presented to Bob Biologist as Hyper cards which describe the function and present options as buttons and lists. Bob can type his sequence into a card, or select from Mac or VAX data files as needed. The card then builds necessary VAX and GCG commands to perform his analysis, sends them to the VAX and returns the text or plot results. All of the archane VMS details are hidden from Bob. This HyperGCG stack includes a framework for organizing the GCG analysis functions, the needed communications links (via phone/serial or network/MacTCP connections), a simple sequence editor, file handling routines for VAX and Mac, text and plot output functions. At this point, the stack is still an unfinished skeleton; I have implemented only a few of the GCG functions, and the organization and documentation needs much work. I am not recommending it for Bob or any average user yet. I would like to know if any GCG/Vax system managers or support people want to get your hands on it to test and provide me with feedback, or even add to it. I am not volunteering to finish this anytime soon. I have enough other tasks. If there is enough interest, and if people at GCG want to make their package more palatable to VMS-o-phobic biologists, then they might want to support something like this (changes would be needed with each new software release). It is at the stage where only Hypercard/Hypertalk programming ability, and a knowledge of VMS commands, is needed to flesh it out. -- Don Don.Gilbert@IuBio.Bio.Indiana.Edu biocomputing, biology dept., indiana univ., bloomington, in 47405