Dear IUBio Archive:

   Enclosed is version 3.50 of LINKAGE-1 for the Macintosh.


LINKAGE-1 (Macintosh)

   LINKAGE-1 is a Pascal computer program designed to aid the geneticist in the detection and estimation of linkage in segregating progenies.

   With LINKAGE-1, version 3.50, the user can analyze both single-individual genotype data, as well as pre-tabulated pairwise two-locus data in a single run.

   Data generated from a variety of genetic situations can be analyzed.  Both F2 and backcross types in addition to all other combinations of the allowable single factor segregation ratios are permitted.  The program accepts both dominant (3:1 and 1:1 expected ratios) and codominant (1:1, 1:2:1 and 1:1:1:1 expected ratios) genes as segregating loci.

   Output consists of single locus goodness-of-fit tests to expected ratios and all possible pairwise linkage tests.  Recombination estimates are given in standard map units and Kosambi map units.

   This archive contains a combination of six files and folders:

       File                       Description
       -------------------------------------------------------
       Linkage-1           Linkage analysis application
       testdata            Sample test data
       Source Files        Folder containing program source code, etc.
       L1_Man01.ps         Cover page to Linkage-1
       L1_Man02.ps         Index to manual
       L1_Man03.ps         Body of Linkage-1 manual


   Use BinHex 4.0 to dehex this self-extracting archive

   The manual is in Postscript format can be printed on any PostScript compatible printer.  Use a program such as the LaserWriter Utility, PSPrint, etc. to send these PostScript files to your printer.

   Please send any comments or questions to the address below.

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| Karl A. Suiter, Duke University, Zoology Dept., Durham, NC   27706    |
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| Voice: (919) 684-2251      |   INTERNET:  ksuiter@acpub.duke.edu      |
| FAX:   (919) 684-6168      |   COMPUSERV: 72701,3543@compserv.com     |
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