MacStripe is a program for the prediction and analysis of potential coiled-coil regions in protein sequences. A new and much improved version (2.0a1) is available to download now from: http://www.york.ac.uk/depts/biol/units/coils/coilcoil.html MacStripe is the ideal tool for anyone who wants to explore potential alpha-helical coiled coils in the sequence of their protein. With a full Macintosh interface, the results of analyses (raw data or publication quality plots) can easily be exported to other software. The "Inspector" window acts like a magnifying glass so you can study your protein on a residue-by-residue basis. MacStripe uses the algorithm of Andrei Lupas's COILS2 for detailed and reliable coiled-coil predictions. System Requirements: Macintosh with 68030, '040 or PowerPC processor; Colour Quickdraw; System 7.0 or better. Features: * Full Macintosh Interface * Uses established Lupas algorithm for coiled coil prediction * Full control of prediction parameters (matrix, window length, weighting) * Interactive exploration of coiled coil with "Inspector" window * Imports sequences from DNA Strider or DNASTAR formats * Reads sequences from text files in plain, FASTA or Staden formats * Uses FPU (where present) for maximum calculation speed * Plots optionally show 'skips' or 'stutters' in coiled coil which may be structurally important * Plots can be copied and pasted into other applications, saved as PICT files, or printed * Detailed statistics can be imported into spreadsheet or graphing programs * It's FREE! Please don't hesitate to contact me with suggestions, bug reports or complaints. Don't forget to check out the coiled-coil prediction web page for more information about MacStripe or other coiled-coil prediction resources.